Publicaciones

PUBLICACIONES PERIODO 2020-2021

  1. Araya J, Bello F, Shivashankar G, Neira D, Durán-Aniotz C, Acosta ML, Escobar MJ, Hetz C, Chacón M, Palacios AG. (2021). Retinal ganglion cells functional changes in a mouse model of alzheimer’s disease are linked with neurotransmitter alterations.  J Alzheimers Dis. doi: 10.3233/JAD-201195.
  2. Arriagada-Diaz J, Prado-Vega L, Cárdenas Díaz AM, Ardiles AO, Gonzalez-Jamett AM. (2020) Dynamin Superfamily at Pre- and Postsynapses: Master Regulators of Synaptic Transmission and Plasticity in Health and Disease. Neuroscientist. 2020 Dec 10:1073858420974313. doi: 10.1177/1073858420974313.
  3. Aspé-Sánchez M, Mengotti P, Rumiati R, Rodríguez-Sickert C, Ewer J, Billeke P. (2020) Late Frontal Negativity Discriminates Outcomes and Intentions in Trust-Repayment Behavior. Front Psychol. 11:532295. doi: 10.3389/fpsyg.2020.532295.
  4. Balboa E, Saavedra F, Cea LA, Ramírez V, Escamilla R, Vargas AA, Regueira T, Sáez JC. (2020) Vitamin E Blocks Connexin Hemichannels and Prevents Deleterious Effects of Glucocorticoid Treatment on Skeletal Muscles. Int J Mol Sci. 21(11):E4094. doi: 10.3390/ijms21114094.
  5. Barria-Urenda M, Garate JA. (2020) Entropy deepens loading chemical potentials of small alcohols by narrow carbon nanotubes. Phys Chem Chem Phys. 22(39):22369-22379. doi: 10.1039/d0cp03426f
  6. Bravo-Tobar ID, Fernández P, Sáez JC, Dagnino-Subiabre A. (2021) Long-term effects of stress resilience: Hippocampal neuroinflammation and behavioral approach in male rats. J Neurosci Res. 2021 Jun 29. doi: 10.1002/jnr.24902.
  7. Carmona EM, Fernandez M, Alvear-Arias JJ, Neely A, Larsson HP, Alvarez O, Garate JA, Latorre R and Gonzalez C (2021) The voltage sensor is responsible for ΔpH dependence in Hv1 channels. Proc Natl Acad Sci U S A 118(19), e2025556118. doi:10.1073/pnas.2025556118
  8. Castro S, El-Deredy W, Battaglia D, Orio P. (2020) Cortical ignition dynamics is tightly linked to the core organisation of the human connectome. PLoS Comput Biol. 16(7):e1007686. doi: 10.1371/journal.pcbi.1007686
  9. Cavieres-Lepe J, Ewer J (2021) Reciprocal relationship between calcium signaling and circadian clocks: implications for calcium homeostasis, clock function, and therapeutics. Front Mol Neurosci. 14:666673. doi: 10.3389/fnmol.2021.666673
  10. Cavieres-Lepe J, Stuardo N. (2021) Amyloid β Clearance Is Disrupted by Depletion of Low-Density Lipoprotein Receptor-Related Protein 4 (LRP4) in Astrocytes. J Neurosci. 41(17):3749-3751. doi: 10.1523/JNEUROSCI.2352-20.2021.
  11. Cea LA, Fernández G, Arias-Bravo G, Castillo-Ruiz M, Escamilla R, Brañes MC, Sáez JC. (2020) Blockade of Hemichannels Normalizes the Differentiation Fate of Myoblasts and Features of Skeletal Muscles from Dysferlin-Deficient Mice. Int J Mol Sci. 21(17):6025. doi: 10.3390/ijms21176025.
  12. Ceriani R, Calfún C, Whitlock KE. (2020) Phoenixin(smim20), a gene coding for a novel reproductive ligand, is expressed in the brain of adult zebrafish. Gene Expr Patterns. 39:119164. doi: 10.1016/j.gep.2020.119164
  13. Ceriani R, Whitlock KE. (2021) Gonadotropin Releasing Hormone (Gnrh) Triggers Neurogenesis in the Hypothalamus of Adult Zebrafish. Int J Mol Sci. 22(11):5926. doi: 10.3390/ijms22115926.
  14. Chang LY, Ardiles AO, Tapia-Rojas C, Araya J, Inestrosa NC, Palacios AG, Acosta ML (2020) Evidence of synaptic and neurochemical remodeling in the retina of ageing degus. Front Neurosci 14:161. doi: 10.3389/fnins.2020.00161
  15. Choi EJ, Palacios-Prado N, Sáez JC, Lee J. (2020) Identification of Cx45 as a Major Component of GJs in HeLa Cells. Biomolecules. 2020 Sep 29;10(10):1389. doi: 10.3390/biom10101389.
  16. Cid-Jofré V, Gárate-Pérez M, Clark PJ, Valero-Jara V, España RA, Sotomayor-Zárate R, Cruz G, Renard GM. (2020) Chronic modafinil administration to preadolescent rats impairs social play behavior and dopaminergic system. Neuropharmacology. 183:108404. doi: 10.1016/j.neuropharm.2020.108404.
  17. Cisterna BA, Vargas AA, Puebla C, Fernández P, Escamilla R, Lagos CF, Matus MF, Vilos C, Cea LA, Barnafi E, Gaete H, Escobar DF, Cardozo C, Sáez JC (2020) Active acetylcholine receptors prevent the atrophy of skeletal muscles and favor reinnervation. Nat Commun. 11(1):1073. doi: 10.1038/s41467-019-14063-8
  18. Coronel-Oliveros C, Castro S, Cofré R, Orio P (2021) Structural features of the human connectome that facilitate the switching of brain dynamics via noradrenergic neuromodulation Front. Comput. Neurosci. 15:687075. doi: 10.3389/fncom.2021.687075
  19. Coronel-Oliveros C, Cofré R, Orio P. (2021) Cholinergic neuromodulation of inhibitory interneurons facilitates functional integration in whole-brain models. PLoS Comput Biol. 17(2):e1008737. doi: 10.1371/journal.pcbi.1008737
  20. Dagnino-Subiabre A. Resilience to stress and social touch. Current Opinion in Behavioral Sciences. 2021 Aug 31. doi: 10.1016/j.cobeha.2021.08.011.
  21. Dagnino-Subiabre A. Stress and Western diets increase vulnerability to neuropsychiatric disorders: A common mechanism. Nutr Neurosci. 2021 Aug;24(8):624-634. doi: 10.1080/1028415X.2019.1661651.
  22. Díaz-Franulic I, Raddatz N, Castillo K, González-Nilo FD, Latorre R. (2020) A folding reaction at the C-terminal domain drives temperature sensing in TRPM8 channels. Proc Natl Acad Sci U S A. 117(33): 20298-20304. doi: 10.1073/pnas.2004303117.
  23. Du X, Carvalho-de-Souza JL, Wei C, Carrasquel-Ursulaez W, Lorenzo Y, Gonzalez N, Kubota T, Staisch J, Haine T, Petrossiana N, Xu M, Latorre R, Bezanilla F and Gomez CM (2020) Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia. Proc Natl Acad Sci U S A. 117(11):20298-20304. doi: 10.1073/pnas.1920008117
  24. Elgueta-Reyes M, Martínez-Pinto J, Renard GM, Sotomayor-Zárate R. (2021) Neonatal programming with sex hormones: Effect on expression of dopamine D1 receptor and neurotransmitters release in nucleus accumbens in adult male and female rats. Eur J Pharmacol. 24:174118. doi: 10.1016/j.ejphar.2021.174118
  25. Escobar AP, Martínez-Pinto J, Silva-Olivares F, Sotomayor-Zárate R, Moya PR. (2021) Altered Grooming Syntax and Amphetamine-Induced Dopamine Release in EAAT3 Overexpressing Mice. Front Cell Neurosci. 15:661478. doi: 10.3389/fncel.2021.661478. eCollection 2021.
  26. Fernández G, Arias-Bravo G, Bevilacqua JA, Castillo-Ruiz M, Caviedes P, Sáez JC, Cea LA. (2020) Myofibers deficient in connexins 43 and 45 expression protect mice from skeletal muscle and systemic dysfunction promoted by a dysferlin mutation. Biochim Biophys Acta Mol Basis Dis. 1866(8):165800. doi: 10.1016/j.bbadis.2020.165800.
  27. Figueroa VA, Jara O, Oliva CA, Ezquer M, Ezquer F, Retamal MA, Martínez AD, Altenberg GA, Vargas AA. (2020) Contribution of Connexin Hemichannels to the Decreases in Cell Viability Induced by Linoleic Acid in the Human Lens Epithelial Cells (HLE-B3) Front Physiol. 10:1574. doi: 10.3389/fphys.2019.01574.
  28. Flores-Muñoz C, Gómez B, Mery E, Mujica P, Gajardo I, Córdova C, Lopez-Espíndola D, Durán-Aniotz C, Hetz C, Muñoz P, Gonzalez-Jamett AM, Ardiles ÁO. (2020) Acute Pannexin 1 Blockade Mitigates Early Synaptic Plasticity Defects in a Mouse Model of Alzheimer’s Disease. Front Cell Neurosci. 14:46. doi: 10.3389/fncel.2020.00046.
  29. Flores-Muñoz C, Maripillán J, Vásquez-Navarrete J, Novoa-Molina J, Ceriani R, Sánchez HA, Abbott AC, Weinstein-Oppenheimer C, Brown DI, Cárdenas AM, García IE, Martínez AD. (2021) Restraint of Human Skin Fibroblast Motility, Migration, and Cell Surface Actin Dynamics, by Pannexin 1 and P2X7 Receptor Signaling. Int J Mol Sci. 22(3):1069. doi: 10.3390/ijms22031069.
  30. Fuente FP, Nocetti D, Sacristán C, Ruiz P, Guerrero J, Jorquera G, Uribe E, Bucarey JL, Espinosa A, Puente L. (2020) Physalis peruviana L. Pulp Prevents Liver Inflammation and Insulin Resistance in Skeletal Muscles of Diet-Induced Obese Mice. Nutrients. 12(3):700. doi: 10.3390/nu12030700.
  31. Fuenzalida M, Chiu CQ, Chávez AE. (2020) Muscarinic Regulation of Spike Timing Dependent Synaptic Plasticity in the Hippocampus. Neuroscience. 2020 Aug 20:S0306-4522(20)30524-8. doi: 10.1016/j.neuroscience.2020.08.015
  32. Gabaldón C, Legüe M, Palominos MF, Verdugo L, Gutzwiller F, Calixto A. (2020) Intergenerational Pathogen-Induced Diapause in Caenorhabditis elegans Is Modulated by mir-243. mBio. 11(5):e01950-20. doi: 10.1128/mBio.01950-20.
  33. García-Campos P, Báez-Matus X, Jara-Gutiérrez C, Paz-Araos M, Astorga C, Cea LA, Rodríguez V, Bevilacqua JA, Caviedes P, Cárdenas AM. (2020) N-Acetylcysteine Reduces Skeletal Muscles Oxidative Stress and Improves Grip Strength in Dysferlin-Deficient Bla/J Mice. Int J Mol Sci. 21(12):4293. doi: 10.3390/ijms21124293.
  34. García-Rodríguez C, Bravo-Tobar ID, Duarte Y, Barrio LC, Sáez JC. (2021) Contribution of non-selective membrane channels and receptors in epilepsy. Pharmacol Ther. 2021 Sep 2:107980. doi: 10.1016/j.pharmthera.2021.107980. Online ahead of print.
  35. Gatica M, Cofré R, Mediano PAM, Rosas F, Orio P, Diez I, Swinnen SP, Cortes J. (2021) High-order interdependencies in the aging brain. Brain Connect. doi: 10.1089/brain.2020.0982.
  36. Giaume C, Naus CC, Sáez JC, Leybaert L. (2021) Glial Connexins and Pannexins in the Healthy and Diseased Brain. Physiol Rev. 101(1):93-145. doi: 10.1152/physrev.00043.2018.
  37. González-Casanova J, Schmachtenberg O, Martínez AD, Sanchez HA, Harcha PA, Rojas-Gomez D. (2021) An Update on Connexin Gap Junction and Hemichannels in Diabetic Retinopathy. Int J Mol Sci. 22(6):3194. doi: 10.3390/ijms22063194.
  38. Guajardo FG, Velásquez VB, Raby D, Núñez-Vivanco G, Iturriaga-Vásquez P, España RA, Reyes-Parada M, Sotomayor-Zárate R. (2020) Pharmacological Characterization of 4-Methylthioamphetamine Derivatives. Molecules. 25(22):5310. doi: 10.3390/molecules25225310.
  39. Güiza J, Arriagada J, Rodríguez L, Gutiérrez C, Duarte Y, Sáez JC, Vega JL. (2021) Anti-parasitics drugs that modulates non-selective channels formed by connexins or pannexins. Biochim Biophys Acta Mol Basis Dis. 1867(10):166188. doi: 10.1016/j.bbadis.2021.166188
  40. Harcha PA, Garcés P, Arredondo C, Fernández G, Sáez JC, van Zundert B. (2021) Mast Cell and Astrocyte Hemichannels and Their Role in Alzheimer’s Disease, ALS, and Harmful Stress Conditions. Int J Mol Sci. 22(4):1924. doi: 10.3390/ijms22041924.
  41. Herzog R, Morales A, Mora S, Araya J, Escobar MJ, Palacios AG, and Cofré R (2021) Scalable and accurate method for neuronal ensemble detection in spiking neural networks. PLoS One. 16(7):e0251647. doi:10.1371/journal.pone.0251647
  42. Hinostroza F, Neely A, Araya-Duran I, Marabolí V, Canan J, Rojas M, Aguayo D, Latorre R, González-Nilo FD, Cárdenas AM. (2020) Dynamin-2 R465W mutation induces long range perturbation in highly ordered oligomeric structures. Sci Rep. 10(1):18151. doi: 10.1038/s41598-020-75216-0.
  43. Jorquera G, Echiburú B, Crisosto N, Sotomayor-Zárate R, Maliqueo M, Cruz G. (2020) Metformin during Pregnancy: Effects on Offspring Development and Metabolic FunctionFront Pharmacol. 11:653. doi: 10.3389/fphar.2020.00653.
  44. Jorquera G, Meneses-Valdés R, Rosales-Soto G, Valladares-Ide D, Campos C, Silva-Monasterio M, Llanos P, Cruz G, Jaimovich E, Casas M. (2021) High extracellular ATP levels released through pannexin-1 channels mediate inflammation and insulin resistance in skeletal muscle fibres of diet-induced obese mice. Diabetologia. 2021 Mar 12. doi: 10.1007/s00125-021-05418-2
  45. Jorquera G, Russell J, Monsalves-Álvarez M, Cruz G, Valladares-Ide D, Basualto-Alarcón C, Barrientos G, Estrada M, Llanos P. (2021) NLRP3 Inflammasome: Potential Role in Obesity Related Low-Grade Inflammation and Insulin Resistance in Skeletal Muscle. Int J Mol Sci. 22(6):3254. doi: 10.3390/ijms22063254.
  46. Julio-Pieper M, López-Aguilera A, Eyzaguirre-Velásquez J, Olavarría-Ramírez L, Ibacache-Quiroga C, Bravo JA, Cruz G. (2021) Gut Susceptibility to Viral Invasion: Contributing Roles of Diet, Microbiota and Enteric Nervous System to Mucosal Barrier Preservation. Int J Mol Sci. 22(9):4734. doi: 10.3390/ijms22094734.
  47. Langlet F, Sáez JC, García-Robles MA. (2020) Editorial: Involvement of Tanycytes in the Neuroendocrine Control of Energy Homeostasis. Front Endocrinol (Lausanne). 22;11:464. doi: 10.3389/fendo.2020.00464.
  48. Lea-Carnall CA, Williams SR, Sanaei-Nezhad F, Trujillo-Barreto NJ, Montemurro MA, El-Deredy W, Parkes LM. (2020) GABA Modulates Frequency-Dependent Plasticity in Humans. iScience. 23(11):101657. doi: 10.1016/j.isci.2020.101657.
  49. Legüe M, Aguila B, Calixto A. (2021) Interspecies RNA Interactome of Pathogen and Host in a Heritable Defensive Strategy. Front Microbiol. 12:649858. doi: 10.3389/fmicb.2021.649858.
  50. Li T, Niu J, Yu G, Ezan P, Yi C, Wang X, Koulakoff A, Gao X, Chen X, Sáez JC, Giaume C, Xiao L. (2020) Connexin 43 deletion in astrocytes promotes CNS remyelination by modulating local inflammation. Glia. 68(6):1201-1212. doi: 10.1002/glia.23770. Epub 2019 Dec 23.
  51. López X, Escamilla R, Fernández P, Duarte Y, González-Nilo F, Palacios-Prado N, Martínez AD, Sáez JC. (2020) Stretch-Induced Activation of Pannexin 1 Channels Can Be Prevented by PKA-Dependent Phosphorylation. Int J Mol Sci. 21(23): 9180. doi: 10.3390/ijms21239180
  52. López X, Palacios-Prado N, Güiza J, Escamilla R, Fernández P, Vega JL, Rojas M, Marquez-Miranda V, Chamorro E, Cárdenas AM, Maldifassi MC, Martínez AD, Duarte Y, González-Nilo FD, Sáez JC. (2021) A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII. Proc Natl Acad Sci USA 118(32):e2108967118. doi: 10.1073/pnas.2108967118.
  53. Maldifassi MC, Momboisse F, Guerra MJ, Vielma AH, Maripillán J, Báez-Matus X, Flores-Muñoz C, Cádiz B, Schmachtenberg O, Martínez AD, Cárdenas AM. (2021) The interplay between α7 nicotinic acetylcholine receptors, pannexin-1 channels and P2X7 receptors elicit exocytosis in chromaffin cells. J Neurochem. 157(6):1789-1808. doi: 10.1111/jnc.15186.
  54. Manterola M, Palominos MF, Calixto A (2021) The heritability of behaviors associated with the host gut microbiota. Frontiers in Immunology 12:658551. doi: 10.3389/fimmu.2021.658551
  55. Mark B, Bustos-González L, Cascallares G, Conejera F, Ewer J. (2021) The circadian clock gates Drosophila adult emergence by controlling the timecourse of metamorphosis. Proc Natl Acad Sci U S A. 118(27):e2023249118. doi: 10.1073/pnas.2023249118.
  56. Martorell A, Wellmann M, Guiffa F, Fuenzalida M, Bonansco C. (2020) P2Y1 receptor inhibition rescues impaired synaptic plasticity and astroglial Ca2+-dependent activity in the epileptic hippocampus. Neurobiol Dis. 2020 Oct 10;146:105132. doi: 10.1016/j.nbd.2020.105132
  57. Miranda HF, Noriega V, Sierralta F, Sotomayor-Zárate R, Prieto JC. (2020) The Antinociceptive Activities of Certain NSAIDS Combinations in Murine Orofacial Test. Drug Res (Stuttg). doi: 10.1055/a-1217-6777.
  58. Morales-Weil K, Moreno M, Ahumada J, Arriagada J, Fuentealba P, Bonansco C, Fuenzalida M. (2020) Priming of GABAergic long-term potentiation by muscarinic receptors. Neuroscience. 2020 Jan 6. pii: S0306-4522(19)30888-7. doi: 10.1016/j.neuroscience.2019.12.033.
  59. Moya-Díaz J, Bayonés L, Montenegro M, Cárdenas AM, Koch H, Doi A, Marengo FD. (2020) Ca2+ -independent and voltage-dependent exocytosis in mouse chromaffin cells. Acta Physiol (Oxf). 228(4):e13417. doi: 10.1111/apha.13417.
  60. Mucarquer JA, Prado P, Escobar MJ, El-Deredy W, Zañartu M. (2020) Improving EEG Muscle Artifact Removal With an EMG Array. IEEE Trans Instrum Meas69(3):815-824. doi: 10.1109/tim.2019.2906967.
  61. Naranjo D, Díaz-Franulic I. (2020) Binding of κ-Conotoxin-PVIIA to Open and Closed Shaker K-Channels Are Differentially Affected by the Ionic Strength. Mar Drugs. 18(11):533. doi: 10.3390/md18110533.
  62. Niesman PJ, Silva V. (2020) Alkalinization of the Synaptic Cleft during Excitatory Neurotransmission. J Neurosci. 40(33):6267-6269. doi: 10.1523/JNEUROSCI.0914-20.2020.
  63. Noriega V, Miranda HF, Prieto JC, Sotomayor-Zárate R, Sierralta F. (2020) Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay. Drug Res (Stuttg). doi: 10.1055/a-1095-5418.
  64. Noriega V, Sierralta F, Poblete P, Aranda N, Sotomayor-Zarate R, Prieto JC, Miranda HF. (2020) Receptors involved in dexketoprofen analgesia in murine visceral pain. J Biosci. 45:94.
  65. Ormazabal P, Herrera K, Cifuentes M, Paredes A, Morales G, Cruz G. (2020) Protective effect of the hydroalcoholic extract from Lampaya medicinalis Phil. (Verbenaceae) on palmitic acid- impaired insulin signaling in 3T3-L1 adipocytes. Obes Res Clin Pract. 14(6):573-579. doi: 10.1016/j.orcp.2020.11.001.
  66. Otero M, Prado-Gutiérrez P, Weinstein A, Escobar MJ, El-Deredy W. (2020) Persistence of EEG Alpha Entrainment Depends on Stimulus Phase at Offset. Front Hum Neurosci. 14:139. doi: 10.3389/fnhum.2020.00139.
  67. Palma X, Thomas-Valdés S, Cruz G. (2021) Acute Consumption of Blueberries and Short-Term Blueberry Supplementation Improve Glucose Management and Insulin Levels in Sedentary Subjects. Nutrients. 13(5):1458. doi: 10.3390/nu13051458.
  68. Palominos MF and Calixto A (2020) Quantification of Bacteria Residing in Caenorhabditis elegans Intestine. BIO-PROTOCOLS 10(9):e3605 doi: 10.21769/BioProtoc.3605
  69. Palominos MF, Whitlock KE. (2021) The Olfactory Organ Is Populated by Neutrophils and Macrophages During Early Development. Front Cell Dev Biol. 8:604030. doi: 10.3389/fcell.2020.604030.
  70. Peñaloza-Sancho V, Pérez-Valenzuela C, Gonzalez C, Jujihara G, Bustos P, Dagnino-Subiabre A. (2021) Cannabinoid receptor type 1 modulates the effects of polyunsaturated fatty acids on memory of stressed rats. Nutr Neurosci. 24(8):583-600. doi: 10.1080/1028415X.2019.1659561.
  71. Plaza-Briceño W, Estay SF, de la Fuente-Ortega E, Gutiérrez C, Sánchez G, Hidalgo C, Chávez AE, Haeger PA. (2020) N-Methyl-d-Aspartate Receptor Modulation by Nicotinamide Adenine Dinucleotide Phosphate Oxidase Type 2 Drives Synaptic Plasticity and Spatial Memory Impairments in Rats Exposed Pre- and Postnatally to Ethanol. Antioxid Redox Signal. 32(9):602-617. doi: 10.1089/ars.2019.7787.
  72. Power A, Brown CA, Sivan M, Lenton A, Rainey T, El-Deredy W, Jones AKP, Watson A. (2020) Individuals with chronic pain have the same response to placebo analgesia as healthy controls in terms of magnitude and reproducibility. Pain. 161(12):2720-2730. doi: 10.1097/j.pain.0000000000001966.
  73. Recabal A, Fernández P, López S, Barahona MJ, Ordenes P, Palma A, Elizondo-Vega R, Farkas C, Uribe A, Caprile T, Sáez JC, García-Robles MA. (2021) The FGF2-induced tanycyte proliferation involves a connexin 43 hemichannel/purinergic-dependent pathway. .J Neurochem. 156(2):182-199. doi: 10.1111/jnc.15188.
  74. Ríos U, Moya PR, Urrejola Ó, Hermosilla J, Gonzalez R, Muñoz P, Moran J, Solervicens P, Jiménez JP. (2020) History of child abuse among patients with bipolar disorders. Rev Med Chile. 148(2):204-210. doi: 10.4067/s0034-98872020000200204.
  75. Riquelme J, Wellmann M, Sotomayor-Zárate R, Bonansco C. (2020) Gliotransmission: A Novel Target for the Development of Antiseizure Drugs. Neuroscientist. 2020 Jan 24:1073858420901474. doi: 10.1177/1073858420901474.
  76. Riquelme-Alcázar J, González-Vargas R, Moya PR. (2020) ABC transporters and drug resistance in epilepsy: biological plausibility, pharmacogenetics and precision medicine. Rev Neurol. 70(1):23-32. doi: 10.33588/rn.7001.2019188.
  77. Rivera B, Campos M, Orio P, Madrid R, Pertusa M. (2020) Negative Modulation of TRPM8 Channel Function by Protein Kinase C in Trigeminal Cold Thermoreceptor Neurons. Int J Mol Sci. 21: 4420. doi:10.3390/ijms21124420
  78. Rivera B, Moreno C, Lavanderos B, Hwang JY, Fernández-Trillo J, Park KS, Orio P, Viana F, Madrid R, Pertusa M. (2021) Constitutive phosphorylation as a key regulator of TRPM8 channel function. J Neurosci. doi: 10.1523/JNEUROSCI.0345-21.2021.
  79. Sáez JC, Contreras-Duarte S, Labra VC, Santibañez CA, Mellado LA, Inostroza CA, Alvear TF, Retamal MA, Velarde V, Orellana JA. (2020) Interferon-γ and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage. .Biochim Biophys Acta Mol Cell Res. 1867(8):118720. doi: 10.1016/j.bbamcr.2020.118720. Epub
  80. Sáez JC, Vargas AA, Hernández DE, Ortiz FC, Giaume C, Orellana JA. (2020) Permeation of Molecules through Astroglial Connexin 43 Hemichannels Is Modulated by Cytokines with Parameters Depending on the Permeant Species. Int J Mol Sci. 21(11):3970. doi: 10.3390/ijms21113970.
  81. Salgado M, García-Robles MÁ, Sáez JC. (2021) Purinergic signaling in tanycytes and its contribution to nutritional sensing. Purinergic Signal. 2021 May 21. doi: 10.1007/s11302-021-09791-w.
  82. Scott RL, Diao F, Silva V, Park S, Luan H, Ewer J, White BH. (2020) Non-canonical Eclosion Hormone-Expressing Cells Regulate Drosophila Ecdysis. iScience. 23(5):101108. doi: 10.1016/j.isci.2020.101108.
  83. Silva V, Palacios-Muñoz A, Okray Z, Adair KL, Waddell S, Douglas AE, Ewer J, . (2020) The impact of the gut microbiome on memory and sleep in Drosophila. J Exp Biol. 224(Pt 3):jeb233619. doi: 10.1242/jeb.233619.
  84. Spaas J, van Veggel L, Schepers M, Tiane A, van Horssen J, Wilson DM 3rd, Moya PR, Piccart E, Hellings N, Eijnde BO, Derave W, Schreiber R, Vanmierlo T. (2021) Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders. Cell Mol Life Sci. 78(10):4615-4637. doi: 10.1007/s00018-021-03802-0.
  85. Tapia F, Olivares J, Schmachtenberg O. (2020 The visual spectral sensitivity of the Chilean recluse spider Loxosceles laeta. J Exp Biol. 223(Pt 2). pii: jeb217133. doi: 10.1242/jeb.217133
  86. Torres FA, Orio P, Escobar MJ (2021). Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model. PLoS Computational Biology 17(7), e1008758.
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