Publicaciones

PUBLICACIONES - 2024

  1. Ahumada-Marchant C, Ancatén-Gonzalez C, Haensgen H, Brauer B, Merino-Veliz N, Droste R, Arancibia F, Horvitz HR, Constantine-Paton M, Arriagada G, Chávez AE, Bustos FJ. (2024) Deletion of VPS50 protein in mouse brain impairs synaptic function and behavior. BMC Biol. 22(1):142. doi: 10.1186/s12915-024-01940-y
  2. Amaya-Rodriguez CA, Carvajal-Zamorano K, Bustos D, Alegría-Arcos M, Castillo K. (2024) A journey from molecule to physiology and in silico tools for drug discovery targeting the transient receptor potential vanilloid type 1 (TRPV1) channel. Front Pharmacol. 14:1251061. doi: 10.3389/fphar.2023.1251061
  3. Ardiles NM, Tapia-Cuevas V, Estay SF, Alcaino A, Velásquez VB, Sotomayor-Zárate R, Chávez AE, Moya PR (2024). Increased forebrain EAAT3 expression confers resilience to chronic stress. J. Neurochem 2024 Sep 8. doi: 10.1111/jnc.16216. Online ahead of print.
  4. Arriagada J, Mercerón D, Ardiles Á, Muñoz P, Paula-Lima A. (2024) Excitatory-inhibitory synaptic imbalance induced by acute intra-hippocampus injections of amyloid-β oligomers. Biochem Biophys Res Commun. 2025 Jan;742:151133. doi: 10.1016/j.bbrc.2024.151133. Epub 2024 Dec 5
  5. Asencio C, Véliz L, Flores-Faúndez E, Azócar L, Echeverría CE, Torres-Estay V, Orellana V, Ramírez-Santelices C, Sotomayor P, Cancino J, Kerr B, Fernandez-Olivares A, Retamal MA, Sáez JC, Godoy AS. (2024) Lack of canonical activities of connexins in highly aggressive human prostate cancer cells. Biol Res. 57(1):97. doi: 10.1186/s40659-024-00565-3
  6. Bayonés L, Guerra-Fernández MJ, Figueroa-Cares C, Gallo LI, Alfonso-Bueno S, Caspe O, Canal MP, Báez-Matus X, González-Jamett A, Cárdenas AM, Marengo FD. (2024) Dynamin-2 mutations linked to neonatal-onset centronuclear myopathy impair exocytosis and endocytosis in adrenal chromaffin cells. J Neurochem. doi: 10.1111/jnc.16194. Online ahead of print
  7. Brauer B, Ancatén-González C, Ahumada-Marchant C, Meza RC, Merino-Veliz N, Nardocci G, Varela-Nallar L, Arriagada G, Chávez AE, Bustos FJ. (2024) Impact of KDM6B mosaic brain knockout on synaptic function and behavior. Sci Rep. 14(1):20416. doi: 10.1038/s41598-024-70728-5
  8. Calbiague-Garcia VC, Chen Y, Cádiz B, Tapia F, Paquet-Durand F, Schmachtenberg O. (2024) Extracellular lactate as an alternative energy source for retinal bipolar cells. J Biol Chem.300(4):106794. doi: 10.1016/j.jbc.2024.106794
  9. Castillo RL, Farías J, Sandoval C, González-Candia A, Figueroa E, Quezada M, Cruz G, Llanos P, Jorquera G, Kostin S, Carrasco R. (2024) Role of NLRP3 Inflammasome in Heart Failure Patients Undergoing Cardiac Surgery as a Potential Determinant of Postoperative Atrial Fibrillation and Remodeling: Is SGLT2 Cotransporter Inhibition an Alternative for Cardioprotection? Antioxidants (Basel). 13(11):1388. doi: 10.3390/antiox13111388
  10. Castillo-Velasquez C, Matamala E, Becerra D, Orio P, Brauchi SE (2024) Optical recordings of organellar membrane potentials and the components of membrane conductance in lysosomes. J Physiol. 602(8):1637-54 . doi: 10.1113/JP283825
  11. Cavieres-Lepe J, Amini E, Zabel M, Nässel DR, Stanewsky R, Wegener C, Ewer J. (2024) Timed receptor tyrosine kinase signaling couples the central and a peripheral circadian clock in Drosophila. Proc Natl Acad Sci U S A. 121(11):e2308067121. doi: 10.1073/pnas.2308067121
  12. Chen Y, Zizmare L, Calbiague V, Wang L, Yu S, Herberg FW, Schmachtenberg O, Paquet-Durand F, Trautwein C (2024) Retinal metabolism: Evidence for uncoupling of glycolysis and oxidative phosphorylation via Cori-, Cahill-, and mini-Krebs-cycle. eLife 12:RP91141 doi: 10.7554/eLife.91141.2
  13. Coronel-Oliveros C, Gómez RG, Ranasinghe K, Sainz-Ballesteros A, Legaz A, Fittipaldi S, Cruzat J, Herzog R, Yener G, Parra M, Aguillon D, Lopera F, Santamaria-Garcia H, Moguilner S, Medel V, Orio P, Whelan R, Tagliazucchi E, Prado P, Ibañez A. (2024) Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole-brain modeling. Alzheimers Dement. 20(5):3228-3250. doi: 10.1002/alz.13788
  14. Coronel-Oliveros C, Medel V, Orellana S, Rodiño J, Lehue F, Cruzat J, Tagliazucchi E, Brzezicka A, Orio P, Kowalczyk-Grębska N, Ibáñez A. (2024) Gaming expertise induces meso-scale brain plasticity and efficiency mechanisms as revealed by whole-brain modeling. Neuroimage. 293: 120633. doi: 10.1016/j.neuroimage.2024.120633
  15. Coronel-Oliveros C, Medel V, Whitaker GA, Astudillo A, Gallagher D, Zepeda-Rivero L, Prado P, El-Deredy W, Orio P, Weinstein A (2024) Elevating Understanding: Linking High-Altitude Hypoxia to Brain Aging Through EEG Functional Connectivity and Spectral Analyses. Netw Neurosci 8 (1): 275–292 doi: 10.1162/netn_a_00352
  16. Cortés BI, Meza RC, Ancatén-González C, Ardiles NM, Aránguiz MI, Tomita H, Kaplan DR, Cornejo F, Nunez-Parra A, Moya PR, Chávez AE, Cancino GI. (2024) Loss of protein tyrosine phosphatase receptor delta PTPRD increases the number of cortical neurons, impairs synaptic function and induces autistic-like behaviors in adult mice. Biol Res.57(1):40. doi: 10.1186/s40659-024-00522-0
  17. Cortés MP, Alonso C, Vinet R, Valdivia-Cortés K, Muñoz-Sagredo L, Bahamondez-Canas TF, Cárdenas AM (2024) Ca2+ signals in human umbilical endothelial cells derived from pregnancy with fetal growth restriction associated with hypertensive disorder. Biomed Rep. 20(5):76. doi: 10.3892/br.2024.1764
  18. Echeverria F, Gonzalez-Sanabria N, Alvarado-Sanchez R, Fernandez M, Castillo K, Latorre R (2024) Large conductance voltage-and calcium-activated K+ (BK) channel in health and disease. Front Pharmacol. Volume 15 – 2024 doi: 10.3389/fphar.2024.1373507
  19. Estay SF, Morales-Moraga C, Vielma AH, Palacios-Muñoz A, Chiu ChQ, Chavez AE (2024) Non-canonical CB1 receptor signaling regulates night visual processing in the inner rat retina. iScience. 109920 doi: 10.1016/j.isci.2024.109920
  20. Ferrada E, Wiedmer T, Wang WA, Frommelt F, Steurer B, Klimek C, Lindinger S, Osthushenrich T, Garofoli A, Brocchetti S, Bradberry S, Huang J, MacNamara A, Scarabottolo L, Ecker GF, Malarstig A, Superti-Furga G. (2024) Experimental and Computational Analysis of Newly Identified Pathogenic Mutations in the Creatine Transporter SLC6A8. J Mol Biol. 436(2):168383. doi: 10.1016/j.jmb.2023.168383
  21. Fuenzalida M, Gómez MI, Ferrada E, Díaz C, Escudero V, González-Guerrero M, Jordana X, Roschzttardtz H. (2024) Using an embryo specific promoter to modify iron distribution pattern in Arabidopsis. Plant Sci. 339:111931. doi: 10.1016/j.plantsci.2023.111931
  22. Gárate-Pérez MF, Cáceres-Vergara D, Tobar F, Bahamondes C, Bahamonde T, Sanhueza C, Guzmán F, Sotomayor-Zárate R, Renard GM. (2024) Effect of lateral septum vasopressin administration on reward system neurochemistry and amphetamine-induced addictive-like behaviors in female rats. Front Pharmacol. 15:1411927. doi: 10.3389/fphar.2024.1411927
  23. García-Rodríguez C, Duarte Y, Ardiles ÁO, Sáez JC. (2024) The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes. J Neurochem. 168(6):1045-1059. doi: 10.1111/jnc.16062
  24. Gómez GI, Alvear TF, Roa DA, Farias-Pasten A, Vergara SA, Mellado LA, Martinez-Araya CJ, Prieto-Villalobos J, García-Rodríguez C, Sánchez N, Sáez JC, Ortíz FC, Orellana JA. (2024) Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage. Biol Res. 57(1):15. doi: 10.1186/s40659-024-00493-2
  25. Gómez GI, García-Rodríguez C, Marillán JE, Vergara SA, Alvear TF, Farias-Pasten A, Sáez JC, Retamal MA, Rovegno M, Ortiz FC, Orellana JA. (2024) Acute activation of hemichannels by ethanol leads to Ca2+-dependent gliotransmitter release in astrocytes. Front Cell Dev Biol. 12:1422978. doi: 10.3389/fcell.2024.1422978
  26. Gómez-Lombardi A, Costa BG, Gutiérrez PP, Carvajal PM, Rivera LZ, El-Deredy W. (2024) The cognitive triad network – oscillation – behaviour links individual differences in EEG theta frequency with task performance and effective connectivity. Sci Rep. 14(1):21482. doi: 10.1038/s41598-024-72229-x
  27. González-González MA, Conde SV, Latorre R, Thébault SC, Pratelli M, Spitzer NC, Verkhratsky A, Tremblay ME, Akcora CG, Hernández-Reynoso AG, Ecker M, Coates J, Vincent KL and Ma B (2024) Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies. Front Integr Neurosci. 18:1321872. doi: 10.3389/fnint.2024.1321872
  28. Herzog-Amunátegui H, Mora S, Prada G, Minonzio JG, Escobar MJ, Cofre R, Palacios AG (2024) A General and Accurate Method for Neuronal Ensemble Detection in Spiking Neural Networks In: Carrillo-Reid, L. (eds) Identification, Characterization, and Manipulation of Neuronal Ensembles. Neuromethods. Humana, New York, NY. Volumen 215 Número 978-1-0716-4208-5 Páginas 69-91 doi: 10.1007/978-1-0716-4208-5_3
  29. Honcamp H, Duggirala SX, Rodiño Climent J, Astudillo A, Trujillo-Barreto NJ, Schwartze M, Linden DEJ, van Amelsvoort TAMJ, El-Deredy W, Kotz SA et al. (2024) EEG resting state alpha dynamics predict an individual’s vulnerability to auditory hallucinations. Cogn Neurodyn . doi: 10.1007/s11571-024-10093-1
  30. Huang J, Osthushenrich T, MacNamara A, Mälarstig A, Brocchetti S, Bradberry S, Scarabottolo L, Ferrada E, Sosnin S, Digles D, Superti-Furga G, Ecker GF. (2024) ProteoMutaMetrics: machine learning approaches for solute carrier family 6 mutation pathogenicity prediction. RSC Adv. 14(19):13083-13094. doi: 10.1039/d4ra00748d
  31. Jara O, Maripillán J, Momboisse F, Cárdenas AM, García IE, Martínez AD. (2024) Differential Regulation of Hemichannels and Gap Junction Channels by RhoA GTPase and Actin Cytoskeleton: A Comparative Analysis of Cx43 and Cx26. Int J Mol Sci. 25(13):7246. doi: 10.3390/ijms25137246
  32. Lamas-Paz A, Hionides-Gutiérrez A, Guo F, Jorquera G, Morán-Blanco L, Benedé-Ubieto R, Mesquita M, Estévez-Vázquez O, Zheng K, Mazariegos M, Vázquez-Ogando E, Blázquez-López E, Asensio I, Mutlu B, Gomez-Santos B, Peligros MI, Vaquero J, Bañares R, Delgado TC, Martínez-Chantar ML, Martínez-Naves E, Sanz-García C, Mohamed MR, Tesolato S, Iniesta P, Gallego-Durán R, Maya-Miles D, Ampuero J, Romero-Gómez M, Martínez-Alcocer A, Sanfeliu-Redondo D, Fernández-Iglesias A, Gracia-Sancho J, Coll M, Graupera I, Ginès P, Ciudin A, Rivera-Esteban J, Pericàs JM, Ávila MA, Frutos MD, Martínez-Cáceres CM, Ramos-Molina B, Aspichueta P, Puigserver P, Nevzorova YA, Cubero FJ. Loss of Cdkn1a protects against MASLD alone or with alcohol intake by preserving lipid homeostasis. JHEP Rep. 7(1):101230. doi: 10.1016/j.jhepr.2024.101230 Online Ahead of Print
  33. Lamas-Paz A, Mesquita M, Garcia-Lacarte M, Estévez-Vázquez O, Benedé-Ubieto R, Gutierrez AH, Wu H, Leal Lasalle H, Vaquero J, Bañares R, Martínez-Naves E, Roa S, Nevzorova YA, Jorquera G, Cubero FJ. (2024) Fecal microbiota transplantation from female donors restores gut permeability and reduces liver injury and inflammation in middle-aged male mice exposed to alcohol. Front Nutr. 11:1393014. doi: 10.3389/fnut.2024.1393014.
  34. Lutz M, Moya PR, Gallorio S, Ríos U, Arancibia M (2024) Effects of Dietary Fiber, Phenolic Compounds, and Fatty Acids on Mental Health: Possible Interactions with Genetic and Epigenetic Aspects. Nutrients. 16(16), 2578 doi: 10.3390/nu16162578
  35. Maldifassi MC, Guerra-Fernández MJ, Ponce D, Alfonso-Bueno S, Maripillán J, Vielma AH, Báez-Matus X, Marengo FD, Acuña-Castillo C, Sáez JC, Martínez AD, Cárdenas AM. (2024) Autocrine activation of P2X7 receptors mediates catecholamine secretion in chromaffin cells. Br J Pharmacol. 181(16):2905-2922. doi: 10.1111/bph.16371
  36. Nasrallah K, Berthoux C, Hashimotodani Y, Chavez AE, Gulfo MC, Luján R, Castillo PE. (2024) Retrograde adenosine/A2A receptor signaling facilitates excitatory synaptic transmission and seizures. Cell Rep. 43(7):114382. doi: 10.1016/j.celrep.2024.114382
  37. Negrón-Oyarzo I, Dib T, Chacana-Véliz L, López-Quilodrán N, Urrutia-Piñones J (2024). Large-scale coupling of prefrontal activity patterns as a mechanism for cognitive control in health and disease: evidence from rodent models. Frontiers in neural circuits, 18, 1286111. doi: 10.3389/fncir.2024.1286111
  38. Offensperger F, Tin G, Duran-Frigola M, Hahn E, Dobner S, Ende CWA, Strohbach JW, Rukavina A, Brennsteiner V, Ogilvie K, Marella N, Kladnik K, Ciuffa R, Majmudar JD, Field SD, Bensimon A, Ferrari L, Ferrada E, Ng A, Zhang Z, Degliesposti G, Boeszoermenyi A, Martens S, Stanton R, Müller AC, Hannich JT, Hepworth D, Superti-Furga G, Kubicek S, Schenone M, Winter GE. (2024) Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 384(6694):eadk5864. doi: 10.1126/science.adk5864
  39. Okolo CA, Maran JJ, Watts A, Maripillan J, Harkiolaki M, Martínez AD, Green CR, Mugisho OO. (2024) Correlative light and X-ray tomography jointly unveil the critical role of connexin43 channels on inflammation-induced cellular ultrastructural alterations. Heliyon. 10(7):e27888. doi: 10.1016/j.heliyon.2024.e27888
  40. Opazo G, Tapia F, Díaz A, Vielma AH and Schmachtenberg O (2024) Prolonged Photobiomodulation with Deep Red Light Mitigates Incipient Retinal Deterioration in a Mouse Model of Type 2 Diabetes. Int J Mol Sci. 25(22), 12128. doi: 10.3390/ijms252212128
  41. Otero M, Prieur-Coloma Y, El-Deredy W, Weinstein A (2024) A High-Resolution LED Stimulator for Steady-State Visual Stimulation: Customizable, Affordable, and Open Source. Sensors 24 (2), 678 doi: 10.3390/s24020678
  42. Palacios-Prado N, Vergara T, Sáez JC. (2024) Enhanced Methodologies for Investigating the Electrophysiological Characteristics of Endogenous Pannexin 1 Intercellular Cell-Cell Channels. Methods Mol Biol. 2801:135-145. doi: 10.1007/978-1-0716-3842-2_11
  43. Parodi J, Mira RG, Fuenzalida M, Cerpa W, Serrano FG, Tapia-Rojas C, Martinez-Torres A, Inestrosa NC. (2024) Wnt-5a Signaling Mediates Metaplasticity at Hippocampal CA3-CA1 Synapses in Mice. Cell Mol Neurobiol. 44(1):76. doi: 10.1007/s10571-024-01512-2
  44. Rozas-Villanueva FM, Orellana, V, Alarcón R, Maripillan J, Martínez AD, Alfaro IE, Retamal MA (2024) Cx40 Levels Regulate Hypoxia-Induced Changes in the Migration, Proliferation, and Formation of Gap Junction Plaques in An Extravillous Trophoblast Cell Model. Cells. 2024 Jul 6;13(13):1150. doi: 10.3390/cells13131150
  45. Sáez JC, Burrell JC, Cahill CM, Cullen DK, Devi LA, Gilbert RJ, Graham ZA, Gurvich VJ, Havton LA, Iyengar R, Khanna R, Palermo EF, Siddiq M, Toro CA, Vasquez W, Zhao W, Cardozo CP. (2024) Pharmacology of boldine: summary of the field and update on recent advances. Front Pharmacol. 15:1427147. doi: 10.3389/fphar.2024.1427147
  46. Salgado M, Márquez-Miranda V, Ferrada L, Rojas M, Poblete-Flores G, González-Nilo FD, Ardiles ÁO, Sáez JC. (2024) Ca2+ permeation through C-terminal cleaved, but not full-length human Pannexin1 hemichannels, mediates cell death. Proc Natl Acad Sci U S A. 121(25):e2405468121. doi: 10.1073/pnas.2405468121
  47. Sitaram R, Sanchez-Corzo A, Vargas G, Cortese A, El-Deredy W, Jackson A, Fetz E. (2024) Mechanisms of brain self-regulation: psychological factors, mechanistic models and neural substrates. Philos Trans R Soc Lond B Biol Sci. 379(1915):20230093. doi: 10.1098/rstb.2023.0093
  48. Tapia F, Peñaloza V, Silva-Olivares F, Sotomayor-Zárate R, Schmachtenberg O, Vielma AH. (2024) Glucagon Increases Retinal Rod Bipolar Cell Inhibition Through a D1 Dopamine Receptor-Dependent Pathway That Is Altered After Lens-Defocus Treatment in Mice. Invest Ophthalmol Vis Sci. 65(1):46. doi: 10.1167/iovs.65.1.46
  49. Terreros G, Pérez MÁ, Muñoz-LLancao P, D’Espessailles A, Martínez EA, Dagnino-Subiabre A (2024) The Neuroprotective Role of Quinoa (Chenopodium quinoa, Wild) Supplementation in Hippocampal Morphology and Memory of Adolescent Stressed Rats. Nutrients. 2024 Jan 27;16(3):381. doi: 10.3390/nu16030381
  50. Tichauer JE, Lira M, Cerpa W, Orellana JA, Sáez JC, Rovegno M. (2024) Inhibition of astroglial hemichannels prevents synaptic transmission decline during spreading depression. Biol Res. 57(1):39. doi: 10.1186/s40659-024-00519-9
  51. Torres FA, Otero M, Lea-Carnall CA, Cabral J, Weinstein A, El-Deredy W. (2024) Emergence of multiple spontaneous coherent subnetworks from a single configuration of human connectome coupled oscillators model. Sci Rep. 14(1):30726. doi: 10.1038/s41598-024-80510-2
  52. Trujillo-Barreto NJ, Araya Galvez D, Astudillo A, El-Deredy W (2024) Explicit Modeling of Brain State Duration Using Hidden Semi Markov Models in EEG Data IEEE Access. 12: 12335-55 doi: 10.1109/ACCESS.2024.3354711
  53. Vásquez W, Toro CA, Cardozo CP, Cea LA, Sáez JC. (2024) Pathophysiological role of connexin and pannexin hemichannels in neuromuscular disorders. J Physiol. 2024 Aug 22. doi: 10.1113/JP286173. Online ahead of print
  54. Vega JL, García A, González J, Sáez JC. (2024) A Dye Uptake Assay to Measure Large-Pore Channel Activity in Trypanosoma cruzi. Methods Mol Biol. 2801:87-95. doi: 10.1007/978-1-0716-3842-2_7
  55. Venegas FC, Rosas D, Delgado N, Estay-Olmos C, Iturriaga-Vásquez P, Rivera-Meza M, Torres GE, Renard GM, Sotomayor-Zárate R. (2024) Early-life exposure to sex hormones promotes voluntary ethanol intake in adulthood. A vulnerability factor to drug addiction. Prog Neuropsychopharmacol Biol Psychiatry. 133:111001. doi: 10.1016/j.pnpbp.2024.111001.
  56. Villanelo F, Minogue PJ, Maripillán J, Reyna‑Jeldes M, Jensen‑Flores J, García IE, Beyer EC, Pérez‑Acle T, Berthoud VM and Martínez AD (2024) Connexin channels and hemichannels are modulated differently by charge reversal at residues forming the intracellular pocket. Biol Res 57:31. doi: 10.1186/s40659-024-00501-5
  57. Wegener C, Amini E, Cavieres-Lepe J, Ewer J. (2024) Neuronal and endocrine mechanisms underlying the circadian gating of eclosion: insights from Drosophila. Curr Opin Insect Sci. 66:101286. doi: 10.1016/j.cois.2024.101286
  58. Zúñiga-Hernández J, Farias C, Espinosa A, Mercado L, Dagnino-Subiabre A, Campo AD, Illesca P, Videla LA, Valenzuela R. (2024) Modulation of Δ5- and Δ6-desaturases in the brain-liver axis. Nutrition. 131:112629. doi: 10.1016/j.nut.2024.112629. Online ahead of print